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pentobarbital will reduce the level or result of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital decreases outcomes of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of CYP3A4 inducers may lessen sufentanil stages and ef